ChIP-Atlas: Target genes

Potential target genes for Sox2

Query protein: Sox2
Distance from TSS: ± 1 kb  ± 5 kb  ± 10 kb
Sort key: SRX736460 | Otic progenitor cells
 
Color legends
  1000 750 500 250 1 0  (Values = Binding scores of MACS2 and STRING)

Download: TSV (text)
Links: Movie and Document for ChIP-Atlas Target Genes
Sox2's Target genes

◢ Sox2: Average

◢ SRX5292052: AtT-20

◢ SRX2000967: Cortex

◢ SRX2000968: Cortex

◢ SRX2000969: Cortex

◢ SRX216288: Embryonic brains

◢ SRX8843749: Embryonic stomach

◢ SRX11540061: EpiLC

◢ SRX11540062: EpiLC

◢ SRX11540063: EpiLC

◢ SRX11540073: EpiLC

◢ SRX11540074: EpiLC

◢ SRX11540075: EpiLC

◢ SRX11540085: EpiLC

◢ SRX11540086: EpiLC

◢ SRX11540087: EpiLC

◢ SRX11540091: EpiLC

◢ SRX11540092: EpiLC

◢ SRX11540093: EpiLC

◢ SRX9641186: EpiLC

◢ SRX9641187: EpiLC

◢ SRX9641188: EpiLC

◢ SRX9641199: EpiLC

◢ SRX9641200: EpiLC

◢ SRX9641201: EpiLC

◢ SRX9641215: EpiLC

◢ SRX9641216: EpiLC

◢ SRX9641217: EpiLC

◢ SRX1410921: EpiSC

◢ SRX1410926: EpiSC

◢ SRX3130182: EpiSC

◢ SRX10157918: Esophageal organoids

◢ SRX10157919: Esophageal organoids

◢ SRX10157920: Esophageal organoids

◢ SRX10157921: Esophageal organoids

◢ SRX10157922: Esophageal organoids

◢ SRX10157923: Esophageal organoids

◢ SRX10157924: Esophageal organoids

◢ SRX10157925: Esophageal organoids

◢ SRX10157958: Esophageal organoids

◢ SRX10157959: Esophageal organoids

◢ SRX003867: ES cells

◢ SRX057760: ES cells

◢ SRX11123496: ES cells

◢ SRX11123497: ES cells

◢ SRX11123498: ES cells

◢ SRX11123499: ES cells

◢ SRX13228088: ES cells

◢ SRX13228090: ES cells

◢ SRX13228158: ES cells

◢ SRX13228160: ES cells

◢ SRX1342337: ES cells

◢ SRX1342338: ES cells

◢ SRX1342339: ES cells

◢ SRX1342340: ES cells

◢ SRX1410236: ES cells

◢ SRX14834578: ES cells

◢ SRX14834579: ES cells

◢ SRX15046818: ES cells

◢ SRX15046819: ES cells

◢ SRX16989252: ES cells

◢ SRX16989253: ES cells

◢ SRX18040244: ES cells

◢ SRX18040246: ES cells

◢ SRX18040248: ES cells

◢ SRX18040250: ES cells

◢ SRX18040252: ES cells

◢ SRX18040254: ES cells

◢ SRX20660262: ES cells

◢ SRX20660263: ES cells

◢ SRX209316: ES cells

◢ SRX2236938: ES cells

◢ SRX2236939: ES cells

◢ SRX2236940: ES cells

◢ SRX2236941: ES cells

◢ SRX2236942: ES cells

◢ SRX2236943: ES cells

◢ SRX2332425: ES cells

◢ SRX2332426: ES cells

◢ SRX2332427: ES cells

◢ SRX2332431: ES cells

◢ SRX2332432: ES cells

◢ SRX2332433: ES cells

◢ SRX23535749: ES cells

◢ SRX23535750: ES cells

◢ SRX23535751: ES cells

◢ SRX23535752: ES cells

◢ SRX236477: ES cells

◢ SRX3087137: ES cells

◢ SRX4017942: ES cells

◢ SRX4017959: ES cells

◢ SRX433130: ES cells

◢ SRX4594913: ES cells

◢ SRX4594914: ES cells

◢ SRX4594915: ES cells

◢ SRX4594916: ES cells

◢ SRX5023740: ES cells

◢ SRX5023741: ES cells

◢ SRX5023742: ES cells

◢ SRX5023743: ES cells

◢ SRX5023744: ES cells

◢ SRX5023745: ES cells

◢ SRX5023746: ES cells

◢ SRX5023747: ES cells

◢ SRX5023748: ES cells

◢ SRX5023749: ES cells

◢ SRX5023750: ES cells

◢ SRX5023751: ES cells

◢ SRX5374733: ES cells

◢ SRX6032059: ES cells

◢ SRX6032060: ES cells

◢ SRX6032061: ES cells

◢ SRX6032062: ES cells

◢ SRX6032071: ES cells

◢ SRX6032072: ES cells

◢ SRX6032073: ES cells

◢ SRX6032074: ES cells

◢ SRX651984: ES cells

◢ SRX6801297: ES cells

◢ SRX6801298: ES cells

◢ SRX6827271: ES cells

◢ SRX6879010: ES cells

◢ SRX750939: ES cells

◢ SRX7653541: ES cells

◢ SRX7653550: ES cells

◢ SRX8517930: ES cells

◢ SRX8517931: ES cells

◢ SRX8517932: ES cells

◢ SRX8517933: ES cells

◢ SRX8517950: ES cells

◢ SRX8517951: ES cells

◢ SRX8517952: ES cells

◢ SRX8517953: ES cells

◢ SRX8517970: ES cells

◢ SRX8517971: ES cells

◢ SRX8517972: ES cells

◢ SRX8517973: ES cells

◢ SRX8713909: ES cells

◢ SRX8994338: ES cells

◢ SRX8994339: ES cells

◢ SRX8994340: ES cells

◢ SRX8994341: ES cells

◢ SRX9486379: ES cells

◢ SRX9486381: ES cells

◢ SRX9486383: ES cells

◢ SRX9641167: ES cells

◢ SRX9641168: ES cells

◢ SRX9641169: ES cells

◢ SRX21482115: Ganglion cells

◢ SRX19952384: Gq-CNO

◢ SRX15046836: Induced trophoblast stem cells

◢ SRX15046837: Induced trophoblast stem cells

◢ SRX1184107: iPSC intermediates

◢ SRX3213542: iPSC intermediates

◢ SRX3213543: iPSC intermediates

◢ SRX897941: iPSC intermediates

◢ SRX897943: iPSC intermediates

◢ SRX3038016: iPS cells

◢ SRX3038017: iPS cells

◢ SRX3038018: iPS cells

◢ SRX3038019: iPS cells

◢ SRX3038020: iPS cells

◢ SRX3038021: iPS cells

◢ SRX3038024: iPS cells

◢ SRX3038027: iPS cells

◢ SRX3038044: iPS cells

◢ SRX3038045: iPS cells

◢ SRX3038046: iPS cells

◢ SRX3038047: iPS cells

◢ SRX3038048: iPS cells

◢ SRX3038049: iPS cells

◢ SRX3038050: iPS cells

◢ SRX3038051: iPS cells

◢ SRX8713913: iPS cells

◢ SRX3544051: Lung epithelium

◢ SRX3544052: Lung epithelium

◢ SRX3544053: Lung epithelium

◢ SRX4518381: Lung squamous cell carcinoma

◢ SRX4518382: Lung squamous cell carcinoma

◢ SRX4518383: Lung squamous cell carcinoma

◢ SRX4518384: Lung squamous cell carcinoma

◢ SRX15046852: MEF

◢ SRX15046853: MEF

◢ SRX22378519: MEF

◢ SRX22378520: MEF

◢ SRX22378521: MEF

◢ SRX22378523: MEF

◢ SRX2831348: MEF

◢ SRX2831349: MEF

◢ SRX2831356: MEF

◢ SRX2831357: MEF

◢ SRX4328949: MEF

◢ SRX4328950: MEF

◢ SRX4328953: MEF

◢ SRX4328954: MEF

◢ SRX4665324: MEF

◢ SRX4665325: MEF

◢ SRX4665326: MEF

◢ SRX4665327: MEF

◢ SRX4665328: MEF

◢ SRX4665329: MEF

◢ SRX8713920: MEF

◢ SRX8713932: MEF

◢ SRX8713936: MEF

◢ SRX209320: mESCs, differentiated

◢ SRX209323: mESCs, differentiated

◢ SRX209326: mESCs, differentiated

◢ SRX209329: mESCs, differentiated

◢ SRX101687: mESC derived neural cells

◢ SRX101688: mESC derived neural cells

◢ SRX101689: mESC derived neural cells

◢ SRX1058354: mESC derived neural cells

◢ SRX1058358: mESC derived neural cells

◢ SRX209313: mESC derived neural cells

◢ SRX209314: mESC derived neural cells

◢ SRX8833456: mESC derived neural cells

◢ SRX8833457: mESC derived neural cells

◢ SRX8833458: mESC derived neural cells

◢ SRX2378798: Neural progenitor cells

◢ SRX2749159: Neural progenitor cells

◢ ERX005682: Neural Stem Cells

◣ SRX736460: Otic progenitor cells

◢ SRX736461: Otic progenitor cells

◢ SRX3205487: Squamous cell carcinoma

◢ SRX3205492: Squamous cell carcinoma

◢ SRX1892806: Stomach

◢ SRX1892807: Stomach

◢ SRX404308: Trophoblast stem cells

◢ SRX19952381: Unclassified

◢ SRX3087129: Unclassified

◢ SRX3087130: Unclassified

◢ SRX3087131: Unclassified

◢ SRX3087132: Unclassified

◢ SRX3087133: Unclassified

◢ SRX3087134: Unclassified

◢ SRX3087135: Unclassified

◢ SRX3087136: Unclassified

◢ SRX3087138: Unclassified

◢ SRX9989367: Unclassified

◢ SRX9989368: Unclassified

◢ SRX9989369: Unclassified

◢ SRX9989370: Unclassified

◢ SRX057755: ZHBTc4

◢ SRX057756: ZHBTc4

◢ SRX057757: ZHBTc4

◢ SRX057758: ZHBTc4

◢ SRX057759: ZHBTc4

◢ SRX2236913: ZHBTc4

◢ SRX2236914: ZHBTc4

◢ SRX2236915: ZHBTc4

◢ SRX2236916: ZHBTc4

◢ SRX2236917: ZHBTc4

◢ SRX2236918: ZHBTc4

◢ SRX404305: ZHBTc4

◢ Sox2: STRING

Srsf7
Calm1
Arl6ip1
Dtd2
Rpl3
Sod2
H4c14
Arih1
Hspa5
Sec61a1
Rab13
Rps27rt
Nsrp1
Taf13
Rmi1
Hnrnpk
Srsf5
Txnl4a
Gm16286
Styxl1
Mdh2
Pdlim5
H4c3
Zfp638
Mapk1
Tmed4
Zfp770
Ddit4
Tti2
Med21
Phrf1
Bbs2
1700037H04Rik
Ints6
Ppm1g
H3f3b
P4ha1
Zmat5
Uqcr10
Wdr61
Tra2b
Sfpq
Strap
Rsrp1
Ppp1r3c
Srsf3
Tbc1d7
Rps9
Drg1
H4f16
Zfp963
Vcpip1
Irs2
Ldha
Rc3h1
Ccnl1
Rplp0
Abraxas1
Puf60
H3c6
Zfp207
Tmco1
Pdss2
Farsa
Etfrf1
Casc1
Nufip2
Appbp2
Psmd4
Eapp
Ints12
Gstcd
Cltc
Slc25a4
Hnrnpab
Elavl2
H4c11
Sec61a2
Glul
H4c4
Exosc2
Mif
Gnai3
Rita1
Ddx54
Peli1
Cdk13
Tex14
Jpt1
Fus
Nars2
Glo1
Mphosph9
2810006K23Rik
Zdhhc3
Exosc7
Npm1
Adpgk
Arrdc2
Zbtb37
Rab18
Srcap
Iqcc
Pcyox1
Tmed9
Tra2a
Psmb2
Dnajb4
Fubp1
Slbp
Paxip1
Spg20
Ostc
Xrra1
Spcs2
Clk4
BC049762
Btg1
H2bc4
H2ac6
Mphosph6
Snrpa1
Dnmt1
Amn1
Anapc10
Abce1
Guf1
Ercc6l2
Oat
Prpf38b
D230025D16Rik
Cbx3
Hnrnpa2b1
Rpl14
Eef1a1
Ier5
Grcc10
Canx
Dhx9
Usp8
Wsb1
Rpl28
Ahcyl1
Rpl22l1
Sgf29
4921524J17Rik
Man1b1
Dctn4
Zfand5
Cdk12
Gtpbp10
Polr2f
1700088E04Rik
Frat1
Bclaf1
Caprin2
Taf5
Insig1
Rab21
Rpusd2
Rps20
Ddx3x
Pbrm1
Rad23a
Gtf3c6
Rc3h2
Nabp1
Nop58
Polr2a
Acer3
Mpzl1
Bub3
Rps28
Ndufa7
Pcnp
Snrpc
Prdx1
H2bc21
H2ac20
H2ac21
Magoh
Pip5k1c
Gtf2h3
Eif2b1
Snrnp70
Napepld
Zdhhc5
Hibadh
Ccdc15
Orc5
Alg1
Mcl1
Zfp655
Htt
2610001J05Rik
Sphk2
Rpl18
Calu
Sdha
Ccdc127
Ankrd10
Arid5a
Ube2h
Lsm14a
Tbrg4
Atad3a
Ywhae
Khdc4
Zc3h8
Ndel1
Poldip3
Leng8
Napb
H2bc12
H2ac12
Eif4g2
Dennd10
Psmd12
Tmem183a
Cirbp
Ubb
Nars
Itpr1
Tuba1a
Impdh2
Zfp322a
Aplp2
Rpl41
BC003965
Errfi1
Sdhc
Mpz
Gga2
Zfp706
Sigmar1
B3galnt2
Pitrm1
Psmg1
Rps27a
Clhc1
Zcchc9
Prnp
Prn
Selenow
H4c9
Slc25a28
Prpf39
Cep295
Smim10l1
Orc4
Mbd5
Paip2b
Ankfy1
Tdrd3
Trim33
Rnaseh1
Clk1
Polg2
Ifrd1
Dld
H3c7
H2bc9
Dlst
H4c8
Vcl
Cdk10
Tsc22d1
Map2k1
Atrnl1
Taf15
Immt
Cnot6
Rpl37a
Cycs
Agpat5
Calm2
Srek1
Aasdh
Cspp1
Cops5
Gstp1
Sp1
Rpl22
Haus1
Slc25a3
Atp5a1
Hax1
4931406C07Rik
Taf1d
Ier5l
Zc3h6
Pkd1
Zkscan1
Nup50
Rpl9
Lias
Ssbp1
Nop10
H2ax
Mbd3
2410002F23Rik
Thrap3
Hdac2
Txlna
Fdft1
Cnbp
Tfrc
Znfx1
Snx5
Mgme1
Top1
Smu1
Rpl21
Ccdc171
Usp36
Jtb
Susd6
Nmt1
Septin11
Clcc1
Zfp146
Cse1l
Nrd1
Wdr70
Mmadhc
Rap1gds1
Map3k7
Tubb4b
Slc18a1
Atp6v1b2
Golga1
Emc8
Gm27021
Cox4i1
Nudcd1
Eny2
Morc3
Gm2a
Map2k2
Ywhaq
Rraga
Csde1
Ewsr1
Rhbdd3
Rbm25
Ssna1
Anapc2
Fkbp3
Ube2s
Aacs
Aldoa
Rbm33
Eif4ebp2
Kansl2
Ggps1
Arid4b
Ipp
Zfp81
Lbh
Cat
Pik3ca
Atad1
Ahctf1
Mettl26
Dcaf10
Rhbdd1
Exo5
Usp42
Setd5
Topors
Smim27
Wdr4
Eif2b3
Hspa8
Eef2
Hnrnpf
Rps15a
Lsm2
Arnt
Grpel2
Slc2a1
Hif1a
Dut
Paip2
Caap1
Lcmt2
Adal
Zdhhc16
Exosc1
Wdr74
Dnajb9
Txnl1
Snupn
Dph7
Nxf1
Pcna
Cabin1
Elp6
Akap8
Ctdp1
Ubap1
Rpl15
Nkiras1
Wdr77
Atp5pb
Scfd1
Pkm
H4c18
Smg5
Tpp2
Rpl7l1
Mtf2
Idh3a
Rbm22
Serf2
Plekha4
Ppp1r15a
Plk2
Septin2
Hdlbp
Tbcc
Zfp292
Tent2
Slc30a5
Psmd3
Rnf141
Trappc1
Cntrob
Adprh
Srp68
Jun
Zfp157
Rpl23
Nedd4
Tax1bp1
Skp1
Prkcsh
Ccdc151
Morc2a
Cnih4
Myl6
Tmem68
Tgs1
Urgcp
Mrm3
Glod4
Uspl1
Tor1aip2
Mblac1
Ttc9c
Hnrnpul2
Cherp
Uqcrfs1
Anp32e
Sumf2
Exosc4
Manf
Clpp
Ndufc1
Pcif1
1810055G02Rik
Ppib
Kmt5c
Ranbp2
Selenos
Zfp568
Rpl36a
Tmem39a
B3gat3
Stx12
Pnpla8
Tmem30a
Stmn1
Cln8
Syn1
Ptpn4
Tob1
Nmral1
Ptges3
Psmd7
AW549877
Sash1
Ciao3
Srpr
Foxred1
Ier2
Eif5
Hyou1
H4c6
Eif2s2
Mybbp1a
Eprs
Tubb2a
Rps15
Ppia
Ccnd2
Spty2d1
Asph
H2bc15
H2ac15
Ddx39a
Oga
Ywhag
Mars2
H13
P4hb
Ntmt1
Gsk3b
Dnaja1
Rpl26
Acad12
Zzz3
4932438A13Rik
Api5
Asah1
Slc9a1
Ing1
Atf4
Capzb
Mapre2
Max
Smndc1
Zswim1
Xrcc6
Desi1
Ubn1
Glyr1
Cenpt
Cfdp1
Park7
Cdc42bpb
Xpa
Gpam
Bicd1
Zwilch
Rpl4
Cdc42
Psmg4
Dnaja3
Alg11
Atp7b
Ccdc107
Rpl5
Fbxw11
Plpp3
Fam118b
Rpusd4
Smarcb1
Cd164
Nek1
Pomp
Pacc1
Swt1
Trmt1l
Baiap2
Eid2
Tubgcp5
Rnf4
Mmaa
Romo1
Nfs1
G2e3
Sae1
H2az1
Ddx5
Pknox1
Cep95
H2bc6
Tdrkh
Trap1
Dapk3
Nop14
Grk4
Papss1
Gpt2
Cct8
Ddx56
Nat10
Tasp1
Arpc2
Psen1
Rtn4
Ndufaf5
Esf1
Bola1
Tnfrsf21
Galk2
Cops2
Rars2
Orc3
H2bc14
Sub1
Tank
Dennd5a
Tomm7
Rab30
Rapgef6
Prdx3
Cep20
Cstf2t
Msl2
Dusp1
H2ac13
H2bc13
Trmt44
Psmd5
Washc2
Grpel1
Mrpl1
Senp3
Pmf1
Tmem209
Ssmem1
Them4
Cep83
Rnf10
Naca
Hsp90aa1
Pfdn2
Nit1
Pitpnc1
Cadm1
Prmt5
Tox4
Rab2b
Prmt7
Trit1
Pts
Napa
Zfp438
Gzf1
Usp5
Cdca3
Cox18
Atp5b
Rdm1
Vdac1
Ncoa5
Dele1
Srsf10
Capn10
Ylpm1
Paics
Ppat
Ncan
Scd2
Pih1d1
Aldh16a1
Tcp1
Mrpl18
Rrn3
Nol10
Ccdc174
Bcl2l13
Rps14
G3bp1
Cks2
Rps16
Sap130
Exoc3
Ppp1cb
Brat1
H4c12
Usp10
Selenot
Eif3j2
Eif3j1
Get1
Ppp1r15b
Rbm12b2
3830406C13Rik
Arf4
Sart1
Ranbp6
Ist1
Sart3
Iscu
Ahi1
B3gntl1
Rplp2
Bcas2
Adam10
Fam53a
Tigar
1110004F10Rik
Dzip3
Cip2a
Ociad1
Tubd1
Rps6kb1
Luc7l
Fasn
Rnf34
Phf14
Slc25a40
Dbf4
Rnf146
Fh1
Ndufa4
Tmem230
Nedd9
Nsfl1c
Azin1
Ankrd11
Srsf4
Zbtb21
Negr1
Amd2
Amd1
Brca2
Hmgb1
H3c3
Hsd17b12
Trmt11
Cadm4
Zfp622
Klf2
Entpd6
U2af1
Wipi2
Ccdc88a
Abhd17a
Mtch2
Egfr
Mrpl20
Rbm8a
Rpl27a
Pag1
Rpl8
Acad9
Msra
Sfr1
Atrip
BC031181
Idi1
Zfyve27
Mettl8
Dcaf17
Mcts2
Pygb
Cdc26
Prpf4
Dr1
Mtln
Casc3
Tmed7
Eif1a
Fam207a
Llph
Mat2a
Uba2
Kansl1
Tubb2b
Lrrc28
Cap1
Tomm5
Akap8l
Trim41
Crtc1
Fam162a
Ccdc58
Fam126a
Wdr33
Hnrnpc
Por
Tpm3
Dbnl
Sltm
Fdxr
Ncl
Armc9
Tcerg1
H2ac24
H2ac23
H4bc24
H2bc23
Gapdh
Rfc4
Rab3gap1
Tmem260
Ckb
Zfp267
Uggt2
H3c14
H3c15
H2ac18
H2ac19
Mthfsd
Stap2
Mpnd
H4c2
Ube2v2
Prkar1a
Selenof
Hs2st1
Cdan1
Fem1c
Mrpl28
Ppid
Kidins220
Csrnp2
Rpl27
Rrs1
Pnpla7
Mrpl41
Epn1
Mrpl49
Fau
Cmc2
Cenpn
Nupl1
Herc4
Rpl35a
Iqcg
Efr3a
Zfp869
Btbd9
Cfap97
Pisd
Slc3a2
Lin7c
Mrps35
Gspt1
Tgfbrap1
AI597479
Tmem14c
Serac1
Gtf2h5
Mettl14
Appl1
Armc1
Gm3448
Gm3417
Poln
Haus3
9030025P20Rik
Calr
Caprin1
Ppig
Ilrun
Id3
Jam3
Primpol
Casp3
Calm3
Nsmce3
Cmtm6
Elp1
Abitram
H4c17
Zfp60
Coq9
Ciapin1
Ptcd3
Polr1a
Srfbp1
Mysm1
Actn4
Eif3a
Pgam1
Galnt10
Rheb
Whamm
Polr3d
Prrc2c
Xrn2
Matr3
Ddit3
0610009B22Rik
Ccnt1
BC029722
Eif5a
H2bc1
H2ac1
Ppan
Flcn
Zbed4
Zfp866
Mlf2
Serbp1
Rps13
Prmt9
Srsf11
Ip6k1
Snrpe
Hnrnpm
Lrrc40
Ppp4r3a
Fgfr1
Mttp
Trmt10a
Itfg2
Pik3c2a
Dbi
3110009E18Rik
Topbp1
Ints13
Fgfr1op2
Zfp346
Zfand1
Tcte3
Gm3435
Fam83d
Nubp1
Sumo1
Pabpn1
Utp14b
Acsl3
Zfp329
Pik3r3
Cops8
Sec23ip
Exosc3
Rassf1
Trmo
Garem1
Gpatch3
Pdia4
Ppme1
C2cd3
Dstn
Ttc25
H1f3
Klhl9
Tmsb4x
Pitpnb
Fbxo15
Timm21
Serinc1
Timm23
Parg
Tiparp
Adamts1
Rtn3
Daam1
Sco1
Adprm
Mapkapk2
Mphosph10
Mcee
Zmat2
Bmpr2
Nup188
Dolk
Atf1
Akap13
Tigd5
Eef1d
Rmc1
Cttn
Pfdn4
Ints3
Klf10
Kdsr
Gdpd5
Rab33b
Trnt1
Ccnc
Vps33a
Tob2
Cipc
Nmt2
Ttc1
Meis1
Eno1
Pcdh10
Itch
Gpr19
Cenpw
H4c1
Nme1
Ermard
Csnk1g3
Map3k2
Ensa
Zfp697
Flvcr1
H2bc22
H2ac22
Thnsl1
Enkur
Degs1
Riok2
Slc39a9
Erh
Large1
Pdcd7
Klhl24
Nfkbiz
Add3
Tmem161a
Mrpl2
Klc4
Clcn3
Bag6
Rnh1
Tor1b
Ska3
Mrpl57
Ddhd2